報(bào)告題目:A robust method for designing multistable systems by embedding bistable subsystems
報(bào)告時(shí)間:2022年11月1日(周二)下午3:00
報(bào)告地點(diǎn):騰訊會(huì)議 732164146
報(bào)告人:田天海博士
報(bào)告人單位:澳大利亞莫納什大學(xué)
報(bào)告人簡(jiǎn)介:
田天海,博士,2001年博士畢業(yè)于澳大利亞昆士蘭大學(xué)數(shù)學(xué)系,本科和研究生畢業(yè)于華中科技大學(xué)數(shù)學(xué)學(xué)院,現(xiàn)為澳大利亞莫納什大學(xué)數(shù)學(xué)學(xué)院教授。田天海博士在基因網(wǎng)絡(luò)和細(xì)胞信號(hào)傳導(dǎo)等生物系統(tǒng)的隨機(jī)建模,隨機(jī)動(dòng)力系統(tǒng)的數(shù)值模擬,模型參數(shù)估計(jì),及統(tǒng)計(jì)分析與計(jì)算等方向開(kāi)展過(guò)很多有創(chuàng)新意義的工作,并取得較多的研究成果。獲得過(guò)澳大利亞研究基金會(huì)的“未來(lái)研究員”和“澳大利亞人研究員”等稱(chēng)號(hào)。共發(fā)表130多篇學(xué)術(shù)論文,其部分研究成果己發(fā)表在高級(jí)別學(xué)術(shù)刊物上。
報(bào)告摘要:
In this talk we discuss a robust method to develop multistable mathematical models by embedding bistable models together. Using the GATA1-GATA2-PU.1 module in hematopoiesis as the test system, we discuss a tristable model based on two bistable models without any high cooperative coefficients, and then modify the tristable model based on experimentally determined mechanisms. The modified model successfully realises four stable steady states and accurately reflects a recent experimental observation showing four transcriptional states. The proposed method is a general approach to develop mathematical models for realising multistability and heterogeneity in complex systems
邀請(qǐng)單位:數(shù)學(xué)與統(tǒng)計(jì)學(xué)院